A16z is the biggest startup accelerator firm that is popular for investing in some of the most inventive and successful firms of the twenty-first century in general. The company was founded in 2009 and has been funding innovative projects since.

YCombinator is another startup accelerator company similar to a16z. Basically, they invest in startups, by funding innovative ideas they want to see more work done on, and they have been doing this for over a decade. Occasionally, they gather up all these ideas and tag them “Request for Startups” or simply RFS. The RFS, from YCombinator, is a comprehensive list, on their website, that the company would like to see more innovation done.

The breakthroughs made by artificial intelligence in the past year are massive. As a result, the solutions provided by AI have prompted a new wave of innovation. These breakthroughs are what fuels these ideas that both companies want to see more development.

This year also, a16z and YC have released the list of ideas that they would like to fund. Identically, both lists encompass ideas in which the application of artificial intelligence will make a transformation across various industries. Although all encompassing, developers with innovative AI ideas outside this list are also encouraged to participate.

Just like these companies, Openfabric’s mission is to help create wealth by giving AI developers and startup businesses a chance to create transformative AI solutions. Basically, we can support developers build the next generation unicorns. We offer an affordable medium to develop AI tools for the advancement of AI development. As such, Openfabric AI tools create a very easy opportunity for developers to bring their ideas to life, therefore, enabling them to participate in a16z and YCombinator’s funding program.

Let’s see how Openfabric can support developers building the next generation unicorns.

List of tech ideas for 2025

In 2024, A16Z  and YCombinator released a list of big ideas and RFS, respectively for companies that will be eligible to get funding:

a16z’s big ideas for 2025

Bio Health

1. Common disease focus: Biotech startups will return to targeting major diseases, inspired by GLP-1 success.

2. Health tech democratization: Al and wearables will give patients direct access to health insights.

3. Al super staffing: Al models will help address healthcare staffing shortages by automating administrative work.

Consumer

1. Specialized Al video: Video generation will become specialized for specific uses with better quality.

2. Al memory banks: People will use Al to process their digital footprint for personal insights.

3. Personalized knowledge work: Al will learn to match individual writing styles and workflows.

4. Qualitative data analysis: Al will enable integration of unstructured data with quantitative analysis.

Crypto

1. Al wallets Al systems will manage their own crypto wallets and assets.

2. Autonomous chatbots: Decentralized autonomous chatbots will emerge as independent entities.

3. Proof of personhood: New systems will help verify human identity in an Al world.

4. Crypto app stores: New distribution channels for crypto apps will emerge.

Enterprise+ fintech

1. Al-Powered compliance: Regulation-specific LLMs will simplify compliance processes.

2. Service industry transformation: Al will help service businesses become more scalable.

3. Al-native interfaces: New UI/UX paradigms will emerge for Al-powered software.

Games

1. Al-native storytelling: A next-generation Pixar will emerge using Al for interactive experiences.

2. Living Al companions: Al companions will develop more engaging personalities with virtual social networks.

3. Faceless creators: Al will enable new forms of content creation with hidden identities.

See more on their website.

YC’s “request for startups” – Winter 2025

Government + Public Safety

1. Build LLMs to automate specific government tasks like form filling, application reviews, and document summaries

2. Create computer vision systems for license plate detection and crime prevention

3. Build software that reduces police paperwork time from hours to minutes

4. Create tools for emergency response coordination and dispatch

5. Build platforms that help communities and law enforcement communicate effectively

Manufacturing

1. Build ML-powered robotics systems that reduce labor costs in US manufacturing

2. Create automation tools specifically for American factories competing with overseas production

3. Build specialized industrial robots for factory inspection and maintenance

4. Develop systems that help manufacturers operate efficiently in US industrial hubs

Chips + Engineering

1. Build LLM tools specifically for FPGA design and optimization

2. Create Al systems for ASIC design that reduce development costs

3. Build tools that optimize specialized computation like crypto mining or data compression

4. Develop Al-powered CAD/CAM software that makes engineering tools more accessible

Stablecoins

1. Build platforms for businesses to hold and manage stablecoins

2. Create tools that make it easy for developers to integrate stablecoin payments

3. Build systems for banks to issue their own stablecoins

4. Develop infrastructure for cross-border stablecoin payments and remittances

New Jobs

1. Create tools that help people run local service businesses

2. Build platforms enabling people to earn income providing services online

3. Create systems that help service providers work more efficiently with Al assistance

4. Develop tools that help small businesses operate at the same level as large corporations.

Significance of using Openfabric for Your A16Z and YCombinator Ideas

Openfabric is a frontier that significantly supports the small developer, business or innovator. Specifically, it is a growing ground for the next generation of innovative AI tools and apps. Most importantly, we emphasize on being able to develop AI tools and applications without having to break the bank.

So far, the popular opinion is that AI tools take billions of dollars to build, but we are saying that developers can use our platform to create their innovative AI tools and bring their ideas to life with a small fraction of the original cost.

Furthermore, the collaboration between A16Z and YCombinator fosters the development of artificial intelligence in problem solving. Unfortunately, due to the high cost of developing these tools, many developers may not be able to participate, leaving all the creative products to big companies. Fortunately it does not have to be so. In essence, as a small business owner or developer, you too can participate in this funding program using the resources Openfabric is providing instead. Overall, this is to encourage the development of artificial intelligence by giving small developers the opportunity to showcase their ideas to the world without reservation, financially.

How to use Openfabric to participate

As the technology of the future, Openfabric is always a step ahead in the advancement of AI in the future. With this in mind, Openfabric has developed tools that are in line with the a16z and YC big ideas for 2025. Importantly, all these tools and apps were developed using the Openfabric protocol.

What if you too can use this protocol to develop your own similar tools and apps to participate in the funding program? As a matter of fact, you can! With the testnet.

In addition, building on the Openfabric protocol allows you to develop your tools very easily. Even more, it gives all developers an equal opportunity to create innovative apps and tools for the advancement of Artificial Technology. Furthermore, these apps can give developers the opportunity to get funding from the biggest startup funding organization, a16z. We will see more of these benefits later, in this section however, we are going to analyze each category and the existing Openfabric tools that fit the category

Bio Health

Unfortunately, in many countries, there is a gross shortage of man-power in the healthcare system. However, over the years, different initiatives have been set up to address this issue but they have not yielded significant success. Fortunately, AI, especially AI agents have made patient care and the healthcare industry better than it used to be. Hence, hospitals can care for more patients using AI and save cost while still bringing in more profit from patient care. In addition, the vast information that AI has will make diagnoses and treatment of diseases easier. So, at a16z, here are the ideas they want to focus on to advance AI contribution to Bio Health.

1. Common disease focus: Biotech startups will return to targeting major diseases, inspired by GLP-1 success.

2. Health tech democratization: Al and wearables will give patients direct access to health insights.

3. Al super staffing: Al models will help address healthcare staffing shortages by automating administrative work.

Openfabric Tools

• Openfabric AI Genome Generator

Evidently, one of the problems faced by modern medicine is tailoring treatment for each patient. Being that the treatment methods available today are generalized, patients are significantly exposed to allergies and extreme drug reactions. Especially due to individual differences. However, one can create an AI model of a genome, study it and find out ways to personalize the treatment for that patient.

For that reason, this tool serves as a game changer in the treatment of patients. Therefore, with Openfabric AI genome one can target major disease conditions.

• Openfabric drug discovery tool

Before a drug is released into the market, it undergoes a series of testing at different phases. This is not only time I’m wasting but also resource intensive.

This drug discovery AI application uses different AI models to approach the drug discovery process. Each AI model specializes in a different part of it.

With the AI model, drugs can be developed to target different diseases, especially the major ones that cannot be treated and have not been eradicated.

• Radiology assistant
• DNA visualizer

Consumer

Marketing strategies change over time as a new generation of target customers come. Therefore, marketers and business owners have to keep up. These days, personalization and specialization is important in ensuring the growth of a business. Likewise, AI systems have evolved to create specialized and personalized marketing materials for business to ensure profitability and revenue generation. These a16z ideas are focused on how business interact with consumers:

1. Specialized Al video: Video generation will become specialized for specific uses with better quality.

2. Al memory banks: People will use Al to process their digital footprint for personal insights.

3. Personalized knowledge work: Al will learn to match individual writing styles and workflows.

4. Qualitative data analysis: Al will enable integration of unstructured data with quantitative analysis.

Crypto

Artificial intelligence has made great strides in cryptocurrency markets. As a result, AI tools have evolved to trade, create NFTs and crypto wallets. Gone are the days when the cryptocurrency industry was only operated by individuals with extensive technical knowledge. In reality, AI participation has made it possible for even a newbie to participate in the crypto industry. However, further advancement is still required such as these ideas from a16z.

1. Al wallets Al systems will manage their own crypto wallets and assets.

2. Autonomous chatbots: Decentralized autonomous chatbots will emerge as independent entities.

3. Proof of personhood: Newage systems will help verify human identity in an Al world.

4. Crypto app stores: New distribution channels for crypto apps will emerge.

Enterprise+ fintech

When it comes to LLMs and innovation, the challenge is balance. How can businesses create a balance between LLMs and innovation? The answer is AI. AI-powered compliance systems can simplify the compliance process by using LLMs in innovation. When LLMs are balanced against innovation, such systems will be the beginning of groundbreaking AI-powered innovation. Hence, many businesses can capitalize on and scale with it. In the long run, YC’s ideas for further involvement of AI in this category includes:

1. Al-Powered compliance: Regulation-specific LLMs will simplify compliance processes.

2. Service industry transformation: Al will help service businesses become more scalable.

3. Al-native interfaces: New UI/UX paradigms will emerge for Al-powered software.

Games

Without a doubt, a game is only as interesting as its story and characters. Decades ago, creating these stories and characters took a lot of effort and they lacked personalization. Thus, personalization creates a better gaming experience. In sum, there are numerous benefits of AI in gaming for the gamers and the producers of the games. However, the gaming industry still needs the following ideas from YC for more advancement and better experience.

1. Al-native storytelling: A next-generation Pixar will emerge using Al for interactive experiences.

2. Living Al companions: Al companions will develop more engaging personalities with virtual social networks.

3. Faceless creators: Al will enable new forms of content creation with hidden identities.

Stablecoins

Stablecoins are, chiefly, a safe investment opportunity for investors as they are hardly disturbed by market fluctuations. However, the integration of stablecoins for payment has not been generally adopted globally. Therefore, the creation of AI-powered systems that manage stablecoins, their potential will be limitless; including seamless integration for payments and international payments. AI ideas from YC to foster the growth of stablecoins include:

1. Build platforms for businesses to hold and manage stablecoins

2. Create tools that make it easy for developers to integrate stablecoin payments

3. Build systems for banks to issue their own stablecoins

4. Lastly, develop infrastructure for cross-border stablecoin payments and remittances

New Jobs

Contrary to popular opinion, AI is not here to steal our jobs. On the other hand, AI can help create new jobs and enhance the effectiveness of existing jobs. Fortunately, with these YC’s ideas, AI can create new jobs and open doors for wealth creation for small businesses. These ideas are:

1. Create tools that help people run local service businesses

2. Build platforms enabling people to earn income providing services online

3. Create systems that help service providers work more efficiently with Al assistance

4. Finally, develop tools that help small businesses operate at the same level as large corporations

Benefits of using Openfabric developer tools

Generally, getting access to essential developer tools and resources is a significant challenge for developers in terms of both cost and accessibility. This is because many developer tools such as integrated development environments (IDEs) and Application Programming Interfaces (APIs) come with prices which are very steep for startups. For example, popular tools like Adobe Creative Cloud costs hundreds to thousands of dollars to access per year. As a result, this huge financial burden is a hurdle that many developers can hardly cross.

Additionally, some of these tools have certain restrictive licensing agreements or availability in certain regions that may not favour the accessibility of such tools to developers.

However, with the Openfabric protocol, developers will only need a fraction of money which gives them access to all the tools and testing environments they need for their applications. Furthermore, this access is also limited to a per need basis. Therefore, developers only need to pay for the time they will be using the tools for. Additionally, on the Openfabric protocol, developers can easily create solutions using AI assistance and they will also be able to run these tools or applications seamlessly, thereafter, using our technology.

In conclusion, Openfabric’s decentralized AI platform is the best when it comes to collaborating with AI innovators, data providers and infrastructure providers. Therefore, they are the key to unlocking great potentials and facilitating the creation and use of new intelligent algorithms and services.

Visit the Openfabric WEBSITE today to get started!